This article was originally created by AstraZeneca's Pharmaceutical Research and Development (PHRID) and has been updated and expanded for each update to the main article. The full article can be accessed from the.
The new article, "Preventing Heart Attack with the CRESTOR Program," is based on an analysis of the data collected during the CRESTOR program. The analysis revealed that the program participants were more likely to develop cardiovascular disease (CVD) and stroke (P<0.001) than healthy individuals (P<0.001).
The study also showed that patients who were prescribed Crestor for CVD (n=637) had more frequent heart attacks and strokes than patients who were prescribed the placebo (n=812).
Moreover, the analysis also showed that the patients who were prescribed Crestor for CVD (n=547) had a higher risk of cardiovascular death compared to the patients who were prescribed the placebo (n=812).
In conclusion, the CRESTOR study was conducted to assess the effectiveness of Crestor for reducing the incidence of heart attacks, stroke and CVD in patients with heart disease.
The results of the CRESTOR study demonstrated that patients taking Crestor had a higher incidence of cardiovascular disease and stroke compared to those who were prescribed the placebo. However, the incidence of CVD was not different in the two groups.
The study also showed that patients who were prescribed Crestor for CVD (n=547) had a higher incidence of heart attacks and strokes compared to the patients who were prescribed the placebo (n=812).
In addition, the analysis of the CRESTOR study demonstrated that patients who were prescribed Crestor for CVD (n=547) had a higher incidence of heart attacks and strokes than the patients who were prescribed the placebo (n=812).
In conclusion, the CRESTOR study demonstrated that patients taking Crestor for CVD (n=547) had a higher incidence of heart attacks and strokes than those who were prescribed the placebo (n=812).
In addition, the analysis also revealed that the patients who were prescribed Crestor for CVD (n=547) had a higher incidence of heart attacks and strokes compared to the patients who were prescribed the placebo (n=812).
In conclusion, the CRESTOR study demonstrated that patients taking Crestor for CVD (n=547) had a higher incidence of heart attacks and strokes compared to those who were prescribed the placebo (n=812).
In addition, the analysis also revealed that the patients who were prescribed Crestor for CVD (n=547) had a higher incidence of heart attacks and strokes compared to those who were prescribed the placebo (n=812).
NEW YORK, Oct. 28 --
On Monday, AstraZeneca shares rose 10 cents to $30.76.
The stock's gains have been driven by a new drug called Nexium (marketed under the brand name Crestor) and a $2.50-per-share deal with Pfizer that may open up the gap between the two on a number of market risks.
Analysts said the stock's shares rose 9 cents to $27.16. The stock's gains could be driven by the price of another cholesterol fighter, or the potential to be hit by the latest generic competition from Teva.
The stock fell 2.4 percent at $25.20.
The price of Crestor, the cholesterol-lowering drug used in the treatment of high cholesterol, fell 2.3 percent in Monday's trading on the New York Stock Exchange.
The company said it would be exploring all options before its earnings deadline, but it would still sell the drug if it can sell Crestor, the company said.
"We have an opportunity for the stock to grow in the near future and there are a number of reasons to think we may do that," said Edward Jones analyst Doug Farren. "The question is, does it make sense for us to sell Crestor? I would think that a lot of our customers would be willing to do that."
Shares of AstraZeneca rose 15 cents to $30.44.
Pfizer said the price of Crestor, the world's top-selling cholesterol drug, will be subject to approval by regulators this year and could be worth $5.50-per-share deal, if approved, by late March. The company is also preparing for the launch of its new generic, Humira, in December.
AstraZeneca shares have been declining at about 6 percent this year, partly due to the introduction of generic competition for the cholesterol drug Crestor, which had a market share of 15 percent in the mid-1990s.
Some analysts believe that the market for Crestor could be worth $4-per-share in the near future, if only one-time deals become available.
Pfizer analyst George W. Bush of New York, speaking on condition of confidential trading, said the company's stock has been growing at a slower rate lately because of the lower price of Crestor, and it is now looking for growth. "If it continues to be underperforming, I think it will be very difficult to get it back," said Bush.
The company has said that the cholesterol drug Crestor would be an attractive product for AstraZeneca, as it is among its best sellers, with more than $3 billion in sales in the United States. The drug, which is expected to be a first-ever new competitor to Crestor, has been in a "market with a reputation for quality and efficiency," said company spokeswoman Lynda P. Kesselheim.
Sales of Crestor were $1.5 billion last year, more than double the peak levels of $1.4 billion in sales a decade ago, which was the second-largest market for a cholesterol drug, she said.
AstraZeneca shares fell 2.1 percent to $28.30 on the New York Stock Exchange.
View original contentThe news that AstraZeneca stock fell 2.4 percent, at $25.20 in Monday trading on the New York Stock Exchange, could have a negative impact on the company's earnings.
The stock had its best-of-the-month results in the week ended Sept. 30, trading at $31.10. That's the most recent decline of AstraZeneca's stock, at $28.30. Analysts had said a possible loss was too early, but the decline was expected to be significant enough to offset the loss in earnings, analysts said.
The stock is underperforming on a number of market risks, such as the high cost of developing a new drug, including the possibility of a generic competition from Teva or the need to sell the drug in a lower-than-expected price range.
AstraZeneca's shares rose 11 cents to $31.16. On the New York Stock Exchange, the shares were down 1.8 percent at $27.16.
30, trading at $34.20.
In the second quarter of last year, a study of cholesterol drug Crestor showed that the risk of heart attack was the same as in the first quarter of last year.
AstraZeneca said Thursday it will no longer make its generic cholesterol drug Crestor available to U. S. patients on the condition that patients can bring the medicine to their door in an authorized pharmacy.
The new program, which was announced Wednesday in a U. news release, will include patient assistance programs and free generic medications in the same drug class.
The new program was announced by AstraZeneca at a press conference Thursday evening.
The program will provide AstraZeneca patients access to three different drug classes. The first will be cholesterol-reducing drugs, such as statins, and the second class, antiandrogens, which will be available for those patients who cannot take a medication.
The new program will include patients who qualify by income and the pharmacy technician who works on their prescriptions.
Patients will have a chance to make a decision about their medication and pay a co-payment, which will help patients pay for their own medications at the pharmacy counter.
AstraZeneca will continue to make Crestor available to patients who qualify.
The drug will be available to patients at one of three strengths: 10mg, 20mg and 40mg.
Patients can bring their medication to their door with the following information:
The patient will not be able to bring to their pharmacy the Crestor that had been approved by the U. Food and Drug Administration (FDA).
Patients who qualify by income and the pharmacy technician who works on their prescriptions will have the opportunity to pay the co-payment for Crestor.
Patients will be able to bring the drug to their door with the following information:
The pharmacy technician who works on their prescriptions will work on their prescription at the pharmacy counter for patients who are uninsured or underinsured.
The patient will not be able to bring the drug to their pharmacy with the information below.
Patients will be able to bring the drug to their door with the information below.
The drug maker said Thursday that its cholesterol-lowering drugs Crestor, Zocor and Lipitor would be available in two strengths per month.
The news comes after a report in the Journal-Constitution of the American Medical Association that a study in France had shown that cholesterol-lowering drugs were the best available treatment for some patients with high cholesterol.
The drug makers, which include GlaxoSmithKline, Pfizer, Merck & Co. and Schering-Plough, said it was working on a study to find a way for the companies to market the drugs, but did not say what the results would be. The companies said the results had been obtained before the study was published.
The results of the study were published in the New England Journal of Medicine.
The drug maker said that the drug makers would not have been able to use the information from the studies to decide whether to offer a lower dose.
The report, however, did say that the companies "should not comment on the results of this study."
Crestor and Zocor are the first of a number of drugs in cholesterol-lowering drugs to be on the market. Both are used in the treatment of type 2 diabetes. Crestor is already available in the United States for the treatment of high blood pressure and is on the market in the other class of drugs, such as statins.
The company also said it would not comment on the results of a study on the use of Zocor or Crestor. In a statement, the company said, "The results of the study will not change our beliefs and recommendations about Crestor, Zocor, and Lipitor."
Lipitor is the third statin to lose its patent in more than a decade, with all the other drugs to lose their patent in the same period.
The company said, "It is difficult to predict whether a drug will lose its patent by a different manufacturer. We have no information available to us on whether a new patent will be issued for another drug, or whether the patent may be renewed."
The drug maker said that the company will make "a decision" about whether to continue its research and development efforts.
Lipitor will begin marketing its next version on Jan. 13, but it is not yet clear when it will be.
Lipitor's annual sales, as of April, have been estimated at $4.5 billion.
A statement from Lipitor's sales representative, Jean-Pierre Garnier, said, "The decision to discontinue marketing of Lipitor has been made after the results of the trial and the findings of the trial were submitted to the FDA. The results of the trial and the results of the trial are expected to be submitted in the future."
Lipitor has faced many generic competition for Crestor, while Zocor has a much lower price than the brand-name drug.
The company said, "The generic is the most cost-effective generic for most patients and is in the highest cost category. We believe that this is the most cost-effective generic to date."
AstraZeneca said it was "reviewing" its cholesterol-lowering drugs, including Lipitor and Zocor, for a "good" time. It also is considering other cholesterol-lowering drugs, such as Crestor and Zocor, to treat high cholesterol.
AstraZeneca's patent for Crestor expired in 2012 and has since been pulled.
AstraZeneca said, "We have a significant number of patients who are taking Lipitor and Zocor and we believe that these drugs are not a good choice for them or their doctors or patients."
AstraZeneca is reviewing the patent for Lipitor and Zocor. The new patent will expire on Aug. 18.
The drug maker said that the company would make a decision on whether to continue marketing and development of its other cholesterol-lowering drugs.
AstraZeneca said, "This decision is based on a number of factors, including the results of the trial, the findings of the trial, the results of a previous study of Zocor and the results of the trial."
The company said, "We are reviewing all of the data, including clinical information and the results of the trial. We are committed to working closely with regulatory agencies and the American Hospital Formulary and the American Diabetes Association to address the current and future regulatory issues."AstraZeneca also said it is reviewing the decision to discontinue marketing of Zocor and Crestor.
On June 5, 2023, the US Food and Drug Administration (FDA) will be approving a new drug to treat high cholesterol that is not indicated for the treatment of type 2 diabetes.
AstraZeneca will market a generic version of the drug Crestor to AstraZeneca and will also market a generic version of Nexium (esomeprazole), which is a newer medication in the class of drugs known as proton pump inhibitors. Nexium is the second-best selling drug to AstraZeneca’s Nexium.
AstraZeneca will make a market launch announcement next week. The initial product launch in June 2023, will include a generic version of Nexium (esomeprazole) at a cost of approximately $1.3 billion (U. S.).
This drug, called Nexium (esomeprazole), is the first of its type to be approved to treat obesity and is approved by the FDA for the treatment of type 2 diabetes.
The FDA approved Nexium in May 1997. In 2004, Nexium was the second-best selling drug to AstraZeneca in the class of drugs known as proton pump inhibitors.
AstraZeneca is the first US company to have granted approval for a generic version of the blockbuster drug Crestor (rosuvastatin), a prescription drug for high cholesterol.
AstraZeneca plans to launch the drug in the US on July 27, 2023. The drug is expected to be approved in the fourth quarter of 2023, and the first generic version of Crestor will be available in the US market in the second half of 2023.
The company will market a generic version of the drug Crestor to AstraZeneca and will also market a generic version of Nexium (esomeprazole), which is a newer medication in the class known as proton pump inhibitors. Nexium is the second-best selling drug to AstraZeneca in the class of drugs known as proton pump inhibitors.